Insulin Regular, Human
Brand names: Humulin R U-500, Humulin R U-500 Kwikpen, Novolin R, Afrezza, Humulin R, Novolin R Flexpen
Part of: Insulin
At a glance
- Medicare prescriptions, 2024
- 286,015
- Medicare drug cost
- $212.7M
- Average cost per prescription
- $744
- Clinicians who prescribed it
- 10,325
Where it is prescribed
List the prescribers in any state, county, city or ZIP code →
What it is used for
HUMALOG Mix50/50 is indicated to improve glycemic control in adults with diabetes mellitus.
From the FDA-approved prescribing information (label dated July 2026). Full labels on DailyMed (opens in a new tab)
Who prescribes it
- Endocrinology & Diabetes 24.6%
- Internal Medicine 23.4%
- Family Medicine 21.1%
- Nurse Practitioners 14.6%
- Pharmacists 3.9%
- Physician Assistants 3.6%
- General Practice 3.5%
- Geriatric Medicine 2.1%
- Hospitalist 1.0%
- Nephrology (Kidney) 0.3%
- Pulmonology 0.3%
- Cardiology 0.2%
All prescribers, by place, name or specialty →
Share of Medicare prescriptions written by each specialty. Select one to list its prescribers.
Trend, 2019–2024
Medicare prescriptions fell 30% from 2019 to 2024.
Biggest change by state since 2019
- Maryland −13%
- Louisiana −19%
- Arkansas −19%
- Kentucky −24%
- West Virginia −25%
- Indiana (smallest change) −40%
- Arizona (smallest change) −38%
From CMS’s yearly state and national Part D summaries, which count every prescriber, including those CMS leaves out of its per-clinician data (fewer than 11 prescriptions). That is why these totals are higher than the count at the top of this page. Prescriptions include refills.
Industry payments about this drug
Drug makers reported $444,642 in payments to clinicians that named this drug in 2025 (meals, speaking, consulting and similar).
- Mannkind Corporation $444,642
Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor
Recalls and shortages
Not on the FDA drug shortage list.
No FDA-reported recalls since 2020.
Industry-funded trials
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.