GLP-1 drugs
At a glance
- Medicare prescriptions, 2024
- 19,369,350
- Medicare drug cost
- $24.29B
- Average cost per prescription
- $1,254
- Clinicians who prescribed it
- 197,606
Where it is prescribed
What these drugs are
GLP-1 receptor agonists lower blood sugar in type 2 diabetes; some are also approved for weight management or to lower heart and kidney risk. Most are weekly or daily injections.
Who prescribes it
- Family Medicine 30.1%
- Internal Medicine 23.1%
- Nurse Practitioners 20.5%
- Endocrinology & Diabetes 13.8%
- Physician Assistants 7.0%
- General Practice 0.8%
- Cardiology 0.8%
- Geriatric Medicine 0.7%
- Pharmacists 0.6%
- Nephrology (Kidney) 0.5%
- Hospitalist 0.3%
- Interventional Cardiology 0.2%
Share of Medicare prescriptions written by each specialty.
Drugs in this group
| Drug | Prescriptions |
|---|---|
| Semaglutide (Ozempic, Rybelsus, Wegovy) | 10,791,685 |
| Tirzepatide (Mounjaro, Zepbound) | 4,643,053 |
| Dulaglutide (Trulicity) | 3,762,194 |
| Liraglutide (Victoza 2-Pak, Victoza 3-Pak) | 85,962 |
| Exenatide Microspheres (Bydureon Bcise) | 84,591 |
| Exenatide (Byetta) | 1,865 |
Drugs filled in fewer than 1,000 counties have no page of their own; their national totals are shown here.
Industry payments about this drug
Drug makers reported $48.2M in payments to clinicians that named this group of drugs in 2025 (meals, speaking, consulting and similar).
- Novo Nordisk Inc $28.9M
- Lilly USA, LLC $19.1M
- Eli Lilly and Company $221,087
- Novo Nordisk As $45,232
- Eli Lilly Export S.a. Puerto Rico Branch $15,710
- AstraZeneca Pharmaceuticals LP $2,887
Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor
Recalls and shortages
On the FDA shortage list now
- Liraglutide, Injection, 6 mg/1 mL (NDC 0143-9144-02) (Hikma Pharmaceuticals USA, Inc.)
- Liraglutide, Injection, 6 mg/1 mL (NDC 0143-9144-03) (Hikma Pharmaceuticals USA, Inc.)
- Liraglutide, Injection, 6 mg/1 mL (NDC 0480-3667-20) (Novo Nordisk, Inc.)
- Victoza, Injection, 6 mg/1 mL (NDC 0169-4060-12) (Novo Nordisk, Inc.)
- Saxenda, Injection, 6 mg/1 mL (NDC 0169-2800-15) (Novo Nordisk, Inc.)
- Victoza, Injection, 6 mg/1 mL (NDC 0169-4060-13) (Novo Nordisk, Inc.)
- Liraglutide, Injection, 6 mg/1 mL (NDC 0480-3667-22) (Novo Nordisk, Inc.)
- Liraglutide, Injection, 6 mg/1 mL (NDC 71288-563-85) (Meitheal Pharmaceuticals, Inc.)
6 recalls since 2020
- Aug 2026 · Amneal Pharmaceuticals of New York, LLC · Class II
Defective Delivery System: Possibility of no medication in the prefilled pen. - Apr 2026 · Lupin Pharmaceuticals Inc. · Class II
Presence of particulate matter: a white thread-like structure in the cartridge - Apr 2022 · Cardinal Health Inc. · Class II
TEMPERATURE ABUSE: Products were exposed to temperatures outside of the products labeled storage conditions - Aug 2021 · Eli Lilly & Company · Class II
Labeling: Label error on declared strength - autoinjector devices labeled as 0.75 mg / 0.5 mL actually contain 1.5 mg / 0.5 mL of product. - Mar 2021 · Novo Nordisk Inc · Class II
Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements that could cause a lack of efficacy and damage to the cartridge and pen-injectors. - Mar 2021 · Cardinal Health Inc. · Class II
CGMP Deviations: Intermittent exposure to temperature excursion during storage.
Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)
Industry-funded trials
- A Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS) Recruiting · Eli Lilly and Company
- A Study of Dulaglutide (LY2189265) in Children and Adolescents With Type 2 Diabetes Completed · Eli Lilly and Company
- A Study to Evaluate Safety of Exposure to Wegovy During Pregnancy Enrolling by invitation · Novo Nordisk As
Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.