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GLP-1 drugs

Drug group

At a glance

Medicare prescriptions, 2024
19,369,350
Medicare drug cost
$24.29B
Average cost per prescription
$1,254
Clinicians who prescribed it
197,606

Where it is prescribed

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What these drugs are

GLP-1 receptor agonists lower blood sugar in type 2 diabetes; some are also approved for weight management or to lower heart and kidney risk. Most are weekly or daily injections.

Who prescribes it

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Share of Medicare prescriptions written by each specialty.

Drugs in this group

DrugPrescriptionsMedicare cost
Semaglutide (Ozempic, Rybelsus, Wegovy) 10,791,685 $13.65B
Tirzepatide (Mounjaro, Zepbound) 4,643,053 $5.76B
Dulaglutide (Trulicity) 3,762,194 $4.72B
Liraglutide (Victoza 2-Pak, Victoza 3-Pak) 85,962 $71.5M
Exenatide Microspheres (Bydureon Bcise) 84,591 $88.5M
Exenatide (Byetta) 1,865 —

Drugs filled in fewer than 1,000 counties have no page of their own; their national totals are shown here.

Industry payments about this drug

Drug makers reported $48.2M in payments to clinicians that named this group of drugs in 2025 (meals, speaking, consulting and similar).

  • Novo Nordisk Inc $28.9M
  • Lilly USA, LLC $19.1M
  • Eli Lilly and Company $221,087
  • Novo Nordisk As $45,232
  • Eli Lilly Export S.a. Puerto Rico Branch $15,710
  • AstraZeneca Pharmaceuticals LP $2,887

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Source: CMS Open Payments, general payments (not research), program year 2025. A payment is not evidence of wrongdoing. Payments by doctor

Recalls and shortages

On the FDA shortage list now

  • Liraglutide, Injection, 6 mg/1 mL (NDC 0143-9144-02) (Hikma Pharmaceuticals USA, Inc.)
  • Liraglutide, Injection, 6 mg/1 mL (NDC 0143-9144-03) (Hikma Pharmaceuticals USA, Inc.)
  • Liraglutide, Injection, 6 mg/1 mL (NDC 0480-3667-20) (Novo Nordisk, Inc.)
  • Victoza, Injection, 6 mg/1 mL (NDC 0169-4060-12) (Novo Nordisk, Inc.)
  • Saxenda, Injection, 6 mg/1 mL (NDC 0169-2800-15) (Novo Nordisk, Inc.)
  • Victoza, Injection, 6 mg/1 mL (NDC 0169-4060-13) (Novo Nordisk, Inc.)
  • Liraglutide, Injection, 6 mg/1 mL (NDC 0480-3667-22) (Novo Nordisk, Inc.)
  • Liraglutide, Injection, 6 mg/1 mL (NDC 71288-563-85) (Meitheal Pharmaceuticals, Inc.)

6 recalls since 2020

  • Aug 2026 · Amneal Pharmaceuticals of New York, LLC · Class II
    Defective Delivery System: Possibility of no medication in the prefilled pen.
  • Apr 2026 · Lupin Pharmaceuticals Inc. · Class II
    Presence of particulate matter: a white thread-like structure in the cartridge
  • Apr 2022 · Cardinal Health Inc. · Class II
    TEMPERATURE ABUSE: Products were exposed to temperatures outside of the products labeled storage conditions
  • Aug 2021 · Eli Lilly & Company · Class II
    Labeling: Label error on declared strength - autoinjector devices labeled as 0.75 mg / 0.5 mL actually contain 1.5 mg / 0.5 mL of product.
  • Mar 2021 · Novo Nordisk Inc · Class II
    Temperature Abuse: product samples were stored at temperatures below 32* F which is not in accordance with storage requirements that could cause a lack of efficacy and damage to the cartridge and pen-injectors.
  • Mar 2021 · Cardinal Health Inc. · Class II
    CGMP Deviations: Intermittent exposure to temperature excursion during storage.

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Recalls usually affect specific lots from one maker, not every version of a drug. Class I is the most serious; most drug recalls are Class II. FDA recalls (opens in a new tab)

Industry-funded trials

Sources: CMS Medicare Part D Prescribers by Provider and Drug (2024; prescriptions include refills, and CMS hides counts under 11 per prescriber); U.S. Food and Drug Administration, openFDA (drug labels, NDC directory, enforcement reports, drug shortages); CMS Open Payments 2025; ClinicalTrials.gov. General information only, not medical advice; not yet reviewed by our medical reviewer.